منابع مشابه
Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly.
The responsiveness and diversity of peripheral B-cell repertoire decreases with age, possibly because of B-cell clonal expansions, as suggested by the incidence of serum monoclonal immunoglobulins and of monoclonal chronic lymphocytic leukemia (CLL)-like B lymphocytes in clinically silent adults. We phenotyped peripheral blood cells from 500 healthy subjects older than 65 years with no history ...
متن کاملA human CD5+ B cell clone that secretes an idiotype-specific high affinity IgM monoclonal antibody.
We previously demonstrated the occurrence of a naturally arisen human anti-idiotypic B cell clone, that we transformed with EBV (EBV383). We show evidence that EBV383 not only expresses the CD5 surface Ag, but also contains the 2.7-kb mRNA transcript encoding this protein. In addition, we show the presence of the 3.6-kb mRNA precursor. Most Ig produced by CD5+ B cells are polyreactive natural I...
متن کاملAssociation of myelodysplastic syndrome with CD5+, CD23+ monoclonal B-cell lymphocytosis
Alex F. Sandes, Maria de Lourdes L. F. Chauffaille, Alberto Orfao, Graziella C. Siufi, Maria Regina R. Silva, Mihoko Yamamoto I Universidade Federal de São Paulo (UNIFESP), Disciplina de Hematologia e Hemoterapia, São Paulo/SP, Brazil. II University of Salamanca, Servicio General de Citometria, Department of Medicine and Cancer Research Center (IBMCC-USAL/CSIC), Salamanca, Spain. III Universida...
متن کاملCd5 Maintains Tolerance in Anergic B Cells
Clonal anergy of autoreactive B cells is a key mechanism regulating tolerance. Here, we show that anergic B cells express significant surface levels of CD5, a molecule normally found on T cells and a subset of B-1 cells. Breeding of the hen egg lysozyme (HEL) transgenic model for B cell anergy onto the CD5 null background resulted in a spontaneous loss of B cell tolerance in vivo. Evidence for ...
متن کاملAn alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.
T lymphocytes and a subpopulation of B lymphocytes express the CD5 coreceptor. Its functional importance is evident from the multiple levels and developmental stages of the regulation of its expression. We here report the discovery of a novel regulatory exon upstream of the noncoding region of the CD5 gene in humans. This alternate exon 1 is designated E1B (with the conventional exon 1 renamed ...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2005
ISSN: 1516-8484
DOI: 10.1590/s1516-84842005000400010